Shortly after he was bitten by a radioactive spider that gave him his strange powers, Peter Parker failed to stop a burglar fleeing from police. When that man went on to murder Peter's beloved Uncle Ben, Peter took it upon himself to atone for his sin of inaction - adopting a mantra instilled in him by his Uncle: "With great power must also come great responsibility." But what if Uncle Ben wasn't all he was cracked up to be? What if he was nothing more than a lout and a con artist? What road might Peter travel if his life had been guided by a different mantra: "Look out for number one"?