Utilizing the sci-fi concept of brain transplants as a launching point, White Like She delves into the lives of a cast of diverse characters. Luther Joyce, a middle-aged African-American custodian at a nuclear power facility, is trapped during a core flare-up, which disfigures him horribly. When technicians discover his prone body, they assume him dead and dispose of him. When Luther washes up on Manhattan's Upper West Side, he decides to pursue a doctor who specializes in brain transplants in the hopes of securing such an operation.
Simultaneously, Louella Schwartz, a radical-left, Jewish teenager, also decides to visit said doctor--her purpose: to assassinate him. When their paths cross, nothing will ever be the same again for all parties concerned. Delving into the taboo topics of race relations, political correctness, gender roles and sexual orientations, White Like She paints an uneasy satirical portrait of life in the '90s.